ARTICLE |
|
Year : 2009 | Volume
: 7
| Issue : 14 | Page : 55-59 |
|
Salivary J1-Glucuronidase as a marker for chronic Periodontitis
Uma Sudhakar, R Vijayalakshmi, Pamela Emmadi, N Ambalavanan, M Ramesh Babu
Department of Periodontics, Meenakshi Ammal Dental College, Chennai, India
Correspondence Address:
Source of Support: None, Conflict of Interest: None | Check |
|
|
Aim: This study was conducted to correlate the relationship between J3-glucuronidase activity in whole saliva with severity of periodontal disease.
Methodology: The study population consisted of 20 subjects (14 males and 6 females), selected from the out patient department of periodontics, Meenak:shi Ammal Dental College and Hospital, Chennai. A sample of unstimulated whole saliva and a venous blood sample were obtained from each subject, and a periodontal examination, which included measurement of pocket depth, attachment level, and gingival index was performed. The unmodified saliva samples were frozen at - 20°C and analyzed for -glucuronidase activity. The blood samples were analyzed for number of total leukocytes, neutrophils, lymphocytes and monocytes.
Results: A significant positive relationship was found between increase J3-glucuronidase activity with increase pocket depth and attachment loss. In addition a significant correlation existed between neutrophil count and -glucuronidase activity.
Conclusion: The results suggest that a significant association between periodontal clinical parameters and salivary J3-glucuronidase activity. Due to non-invasive and simple nature of saliva collection when compared to GCF, estimating the level of the enzyme, -glucuronidase in whole saliva might be used as a marker to assess the severity of periodontitis, and a means of monitoring the response to treatment. |
|
|
|
[PDF]* |
|
|
|