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ARTICLE
Year : 2011  |  Volume : 9  |  Issue : 6  |  Page : 481-487

A Biochemical study on an Association between Periodontitis, Rheumatoid arthritis, and Coronary artery diseases


1 Dept. of Biochemistry, Meenakshi Ammal Dental College, MAHER, Meenakshi University, Maduravoyal, Chennai, Tamil Nadu, India
2 Department of Periodontics, Meenakshi Ammal Dental College, MAHER, Meenakshi University, Maduravoyal, Chennai, Tamil Nadu, India
3 Meenakshi Medical College, Meenakshi University, Enathur, Tamil Nadu, India
4 Meenakshi Ammal Dental College, MAHER, Meenakshi University, Maduravoyal, Chennai, Tamil Nadu, India

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Aims and objectives: The aim of the study is to determine the pathophysiology of inflammatory diseases and to gain knowledge of the possible factors that triggers of the inflammation, which may open novel therapeutic approaches. Materials and methods: A total number of 100 subjects with age range of 45-60 years were selected for this study and were divided into four groups. Group-I(control) which consisted of 25 individuals, who were free of periodontitis, rheumatoid arthritis, and coronary artery diseases. Group-II which consisted of 25 individuals, who were diagnosed with periodontal problems (probing depth 5mm), Group-III which consisted of 25 rheumatoid arthritis individuals, who were diagnosed without prior use of disease modifying anti rheumatic drugs, Group-IV which consisted of 25 individuals, who were diagnosed angiographically proven coronary artery disease without prior use of drugs were selected. A biochemical study of inflammatory markers (fibrinogen and C reactive protein, lipid peroxides), antioxidant levels ( -tocopherol, ascorbic acid, reduced glutathione and ceruloplasmin) and lipid profile (total cholesterol, low density lipoprotein, high density lipoprotein, and triglycerides) were carried out in all patients and these results were compared with control. Results: Inflammatory markers and lipid peroxides were observed to be significantly increased (p 0.001), antioxidant levels showed significant decrease (p 0.001) and the lipid profile values were observed to be increased significantly (p 0.001) in all three disease groups as compared to normal individuals. Conclusion: Hence, the present study suggests the importance of assessing biomarkers of inflammation to determine the severity of inflammation and also to evolve targeted treatment strategies for better management of the condition.


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