Journal of Indian Association of Public Health Dentistry

ARTICLE
Year
: 2013  |  Volume : 11  |  Issue : 3  |  Page : 77--84

Nicotine vaccines for smoking cessation-present and future


Richa1, R Yashodha2, Manjunath P Puranik3 
1 Postgraduate student, Dept, of Public health Dentistry, Govt. Dental College & Research Institute Fort, Bangalore, India
2 Associate Professor, Dept, of Public health Dentistry, Govt. Dental College & Research Institute Fort, Bangalore, India
3 Professor & Head Dept, of Public health Dentistry, Govt. Dental College & Research Institute Fort, Bangalore, India

Correspondence Address:
Richa
Postgraduate student, Dept, of Public health Dentistry, Govt. Dental College & Research Institute Fort, Bangalore
India

Background: Worldwide tobacco is the leading cause of preventable death. Anew treatment in smoking cessation and relapse prevention is nicotine vaccination which is based on active immunization against the nicotine molecule. This article aimed to review the mechanism of action, current status of research and future aspects for the development of vaccines against nicotine. Materials & Method: The literature search of publications indexed was carried out in PubMed, Medline, Google scholar databases. Total 25 animal trials, human trials under various phases of clinical trials, unpublished document and cross-sectional survey were reviewed. Results: This immunization will act on immune system to produce nicotine-specific antibodies that sequester nicotine in the blood stream, after inhaling tobacco products. Nicotine vaccines are irreversible, provide protection over years and need booster injections. Efficiency of the vaccines is directly related to the antibody levels which help to optimize the vaccine effect. Nicotine vaccines are today in an advanced stage of clinical evaluation trials. Conclusions: Though, nicotine vaccine has considerable therapeutic potential, they do not target the non pharmacological factors that maintain tobacco dependence. So combination of nicotine vaccine with behavioral interventions would be effective mode to motivate abstinence from tobacco use.


How to cite this article:
Richa, Yashodha R, Puranik MP. Nicotine vaccines for smoking cessation-present and future.J Indian Assoc Public Health Dent 2013;11:77-84


How to cite this URL:
Richa, Yashodha R, Puranik MP. Nicotine vaccines for smoking cessation-present and future. J Indian Assoc Public Health Dent [serial online] 2013 [cited 2024 Mar 29 ];11:77-84
Available from: https://journals.lww.com/aphd/pages/default.aspx/article.asp?issn=2319-5932;year=2013;volume=11;issue=3;spage=77;epage=84;aulast=Richa,;type=0