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ARTICLE
Year : 2007  |  Volume : 5  |  Issue : 10  |  Page : 90-95

Occurrence of gingival overgrowth in post renal transplant patients treated with Cyclosporine- A and its possible associations with periodontal and pharmacological variables


Department of Periodontics, Meenakshi Ammal Dental College & Hospital, Alapakkam Main Road, MaduravoyaChennai - 600 095, India

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Aim: To determine the occurrence of gingival overgrowth in post renal transplant patients treated with Cyclosporine-A and its possible associations with periodontal and pharmacological variables. Materials and Methods: Thirty post renal transplant patients receiving Cyclosporine-A participated in the study. Patients were divided into two groups. Group I (non-responders) and Group ll (responders) based on the Me Gaw's gingival overgrowth index score. Clinical parameters such as Plaque index, Gingival index, Gingival overgrowth index, and pharmacological parameters like Cyclosporine-A dosage, duration of therapy and serum Cyclosporine-A level were evaluated. Results: There was a significant difference observed for serum Cyclosporine-A level, Plaque index, Gingival index, Gingival overgrowth index scores between the two groups (Group-1and II). When gingival overgrowth was correlated with age, gender, Cyclosporine-A dose and duration of therapy there was no significant correlation observed. Conclusion: The findings from this study suggest that post renal transplant patients treated with Cyclosporine-A experience gingival overgrowth. The magnitude of gingival overgrowth appears more related to serum Cyclosporine-A level, plaque and gingival status than age, gender, Cyclosporine-A dosage and duration of therapy.


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