| ARTICLE |
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| Year : 2007 | Volume
: 5
| Issue : 10 | Page : 90-95 |
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Occurrence of gingival overgrowth in post renal transplant patients treated with Cyclosporine- A and its possible associations with periodontal and pharmacological variables
Anitha, Srilakshmi, Uma Sudhakar, T Ramakrishnan, Pamela Emmadi, N Ambalavanan
Department of Periodontics, Meenakshi Ammal Dental College & Hospital, Alapakkam Main Road, MaduravoyaChennai - 600 095, India
Correspondence Address:
 Source of Support: None, Conflict of Interest: None  | Check |
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Aim: To determine the occurrence of gingival overgrowth in post renal transplant patients treated with Cyclosporine-A and its possible associations with periodontal and pharmacological variables.
Materials and Methods: Thirty post renal transplant patients receiving Cyclosporine-A participated in the study. Patients were divided into two groups. Group I (non-responders) and Group ll (responders) based on the Me Gaw's gingival overgrowth index score. Clinical parameters such as Plaque index, Gingival index, Gingival overgrowth index, and pharmacological parameters like Cyclosporine-A dosage, duration of therapy and serum Cyclosporine-A level were evaluated.
Results: There was a significant difference observed for serum Cyclosporine-A level, Plaque index, Gingival index, Gingival overgrowth index scores between the two groups (Group-1and II). When gingival overgrowth was correlated with age, gender, Cyclosporine-A dose and duration of therapy there was no significant correlation observed.
Conclusion: The findings from this study suggest that post renal transplant patients treated with Cyclosporine-A experience gingival overgrowth. The magnitude of gingival overgrowth appears more related to serum Cyclosporine-A level, plaque and gingival status than age, gender, Cyclosporine-A dosage and duration of therapy. |
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