author = {Sharma, Shruti. and Angral, Rajesh. and Saini, Heena.}, title = {{Effect of prophylaxis of amiodarone and magnesium to prevent atrial fibrillation in patients with rheumatic valve disease undergoing mitral valve replacement surgery}}, journal ={Journal of Indian Association of Public Health Dentistry}, volume ={12}, number ={3}, pages = {189-193}, doi = {10.4103/aer.AER_63_20}, year = {2014}, abstract ={Context: Maintenance of sinus rhythm is superior to the incidence of atrial fibrillation (AF) in patients with rheumatic valve disease undergoing mitral valve replacement (MVR) surgery. Aim: To evaluate the effect of prophylactic combination of intravenous (i.v.) amiodarone and magnesium sulfate (MgSO4) in patients undergoing MVR surgery. Materials and Methods: One hundred and twenty patients with valvular heart disease with or without AF were randomly divided into two groups. Group I (n = 60) received amiodarone (3 mg.kg−1 in 20 mL saline) + MgSO4 (30 mg.kg− 1 in 20 mL saline), and Group II (n = 60) received 40 mL of normal saline. The standardized protocol for cardiopulmonary bypass was maintained for all the patients. Statistical Analysis: Continuous variables were expressed as mean ± standard deviation and categorical variables were summarized as frequencies and percentages. Student's independent t-test was employed for comparing continuous variables. Chi-square test was applied for comparing categorical variables. Results: Before surgery, AF was observed in 58.3% of patients in Group I and in 53.3% of patients in Group II (P = 0.581). Postoperatively, in the intensive care unit, 26.7% of the patients in Group I and 71.7% in Group II had AF (P < 0.001). At the time of discharge, 30% of patients in Group I and 73.3% of patients in Group II had AF (P < 0.001). Conclusion: A single combined prophylactic intraoperative dose of i.v. amiodarone and MgSO4 decreased postbypass arrhythmia in comparison to the placebo group in patients of MVR surgery.}, URL ={https://journals.lww.com/aphd/pages/default.aspx/article.asp?issn=2319-5932;year=2014;volume=12;issue=3;spage=189;epage=193;aulast=Sharma;t=6}, eprint ={https://journals.lww.com/aphd/pages/default.aspx/article.asp?issn=2319-5932;year=2014;volume=12;issue=3;spage=189;epage=193;aulast=Sharma;t=6} }